| 9/11/2021 | Charleston Southern | 38 | at | The Citadel (4-7) | 21 | at SoCon | ||
| 9/18/2021 | Monmouth NJ (7-4,6-1) | 41 | at | Charleston Southern | 14 | |||
| 9/25/2021 | Charleston Southern | 28 | at | East Carolina (7-5) | 31 | at AAC | ||
| 10/9/2021 | Charleston Southern | 24 | at | Robert Morris (4-6,3-5) | 31 | |||
| 10/16/2021 | Hampton (5-6,3-4) | 5 | at | Charleston Southern | 35 | |||
| 10/23/2021 | Charleston Southern | 22 | at | North Alabama (3-8,3-4) | 45 | |||
| 10/30/2021 | Campbell (3-8,2-5) | 14 | at | Charleston Southern | 27 | |||
| 11/6/2021 | North Carolina A&T (5-6,3-4) | 21 | at | Charleston Southern | 18 | |||
| 11/13/2021 | Charleston Southern | 32 | at | Gardner-Webb (4-7,2-5) | 24 | 2OT | ||
| 11/20/2021 | Charleston Southern | 7 | at | Georgia (14-1) | 56 | at SEC |
| vs Charleston Southern | vs Other Opponents | Charleston Southern compared to OOs | |
| Record: | 6-4 | 50-54 | |
| Points Scored: | 28.90 | 28.36 | -0.54 |
| Points Allowed: | 24.50 | 27.83 | -3.33 |
| Margin: | 4.40 | 0.53 | -3.87 |
| Total Points: | 53.40 | 56.19 | -2.79 |