| 9/4/2021 | Campbell (3-8) | 7 | at | Liberty | 48 | BigS (1AA) | ||
| 9/11/2021 | Liberty | 21 | at | Troy (5-7) | 13 | at SBC | ||
| 9/18/2021 | Old Dominion (6-7) | 17 | at | Liberty | 45 | CUSA | ||
| 9/24/2021 | Liberty | 21 | at | Syracuse (5-7) | 24 | at ACC | ||
| 10/2/2021 | Liberty | 36 | at | UAB (9-4) | 12 | at CUSA | ||
| 10/9/2021 | Middle Tenn State (7-6) | 13 | at | Liberty | 41 | CUSA | ||
| 10/16/2021 | Liberty | 28 | at | UL Monroe (4-8) | 31 | at SBC | ||
| 10/23/2021 | Liberty | 35 | at | North Texas (6-7) | 26 | at CUSA | ||
| 10/30/2021 | Massachusetts (1-11,1-3) | 17 | at | Liberty | 62 | |||
| 11/6/2021 | Liberty | 14 | at | Mississippi (10-3) | 27 | at SEC | ||
| 11/20/2021 | UL Lafayette (13-1) | 42 | at | Liberty | 14 | SBC | ||
| 11/27/2021 | Army (9-4,3-0) | 31 | at | Liberty | 16 | |||
| 12/18/2021 | Eastern Michigan (7-6) | 20 | vs | Liberty | 56 | Lending Tree Bowl - Mobile AL | MAC |
| vs Liberty | vs Other Opponents | Liberty compared to OOs | |
| Record: | 5-8 | 80-71 | |
| Points Scored: | 21.54 | 27.83 | 6.29 |
| Points Allowed: | 33.62 | 26.79 | 6.83 |
| Margin: | -12.08 | 1.04 | 13.12 |
| Total Points: | 55.16 | 54.62 | 0.54 |