| 8/28/2021 | UTEP (7-6) | 30 | at | New Mexico State | 3 | CUSA | ||
| 9/4/2021 | New Mexico State | 10 | vs | San Diego State (12-2) | 28 | Carson CA | vs MW | |
| 9/11/2021 | New Mexico State | 25 | at | New Mexico (3-9) | 34 | at MW | ||
| 9/18/2021 | South Carolina State (7-5) | 35 | at | New Mexico State | 43 | MEAC (1AA) | ||
| 9/25/2021 | Hawaii (6-7) | 41 | at | New Mexico State | 21 | MW | ||
| 10/2/2021 | New Mexico State | 31 | at | San Jose State (5-7) | 37 | at MW | ||
| 10/9/2021 | New Mexico State | 28 | at | Nevada (8-5) | 55 | at MW | ||
| 10/23/2021 | New Mexico State | 34 | at | Hawaii (6-7) | 48 | at MW | ||
| 11/6/2021 | Utah State (11-3) | 35 | at | New Mexico State | 13 | MW | ||
| 11/13/2021 | New Mexico State | 3 | at | Alabama (13-2) | 59 | at SEC | ||
| 11/20/2021 | New Mexico State | 16 | at | Kentucky (10-3) | 56 | at SEC | ||
| 11/27/2021 | Massachusetts (1-11,1-3) | 27 | at | New Mexico State | 44 |
| vs New Mexico State | vs Other Opponents | New Mexico State compared to OOs | |
| Record: | 10-2 | 77-65 | |
| Points Scored: | 40.42 | 26.70 | -13.72 |
| Points Allowed: | 22.58 | 27.54 | -4.96 |
| Margin: | 17.84 | -0.84 | -18.68 |
| Total Points: | 63.00 | 54.24 | 8.76 |