| 9/4/2021 | UL Lafayette (13-1) | 18 | at | Texas | 38 | SBC | ||
| 9/11/2021 | Texas | 21 | at | Arkansas (9-4) | 40 | at SEC | ||
| 9/18/2021 | Rice (4-8) | 0 | at | Texas | 58 | CUSA | ||
| 9/25/2021 | Texas Tech (7-6,3-6) | 35 | at | Texas | 70 | |||
| 10/2/2021 | Texas | 32 | at | TCU (5-7,3-6) | 27 | |||
| 10/9/2021 | Oklahoma (11-2,7-2) | 55 | vs | Texas | 48 | Dallas TX | ||
| 10/16/2021 | Oklahoma State (12-2,8-2) | 32 | at | Texas | 24 | |||
| 10/30/2021 | Texas | 24 | at | Baylor (12-2,8-2) | 31 | |||
| 11/6/2021 | Texas | 7 | at | Iowa State (7-6,5-4) | 30 | |||
| 11/13/2021 | Kansas (2-10,1-8) | 57 | at | Texas | 56 | OT | ||
| 11/20/2021 | Texas | 23 | at | West Virginia (6-7,4-5) | 31 | |||
| 11/26/2021 | Kansas State (8-5,4-5) | 17 | at | Texas | 22 |
| vs Texas | vs Other Opponents | Texas compared to OOs | |
| Record: | 7-5 | 89-55 | |
| Points Scored: | 31.08 | 29.08 | -2.00 |
| Points Allowed: | 35.25 | 24.85 | 10.40 |
| Margin: | -4.17 | 4.23 | 8.40 |
| Total Points: | 66.33 | 53.93 | 12.40 |