| 9/4/2021 | Rice | 17 | at | Arkansas (9-4) | 38 | at SEC | ||
| 9/11/2021 | Houston (12-2) | 44 | at | Rice | 7 | AAC | ||
| 9/18/2021 | Rice | 0 | at | Texas (5-7) | 58 | at B12 | ||
| 9/25/2021 | Texas Southern (3-8) | 34 | at | Rice | 48 | SWAC (1AA) | ||
| 10/2/2021 | Southern Miss (3-9,2-6) | 19 | at | Rice | 24 | |||
| 10/16/2021 | Rice | 0 | at | Texas-San Antonio (12-2,8-1) | 45 | |||
| 10/23/2021 | Rice | 30 | at | UAB (9-4,6-2) | 24 | |||
| 10/30/2021 | North Texas (6-7,5-3) | 30 | at | Rice | 24 | OT | ||
| 11/6/2021 | Rice | 24 | at | UNC-Charlotte (5-7,3-5) | 31 | OT | ||
| 11/13/2021 | Western Kentucky (9-5,7-2) | 42 | at | Rice | 21 | |||
| 11/20/2021 | Rice | 28 | at | UTEP (7-6,4-4) | 38 | |||
| 11/27/2021 | Louisiana Tech (3-9,2-6) | 31 | at | Rice | 35 |
| vs Rice | vs Other Opponents | Rice compared to OOs | |
| Record: | 8-4 | 75-66 | |
| Points Scored: | 36.17 | 30.70 | -5.47 |
| Points Allowed: | 21.50 | 28.30 | -6.80 |
| Margin: | 14.67 | 2.40 | -12.27 |
| Total Points: | 57.67 | 59.00 | -1.33 |