| 8/28/2010 Langston (NAIA) 28 at Incarnate Word (D2) 20 |
| 9/2/2010 Taylor (NAIA) 42 at Anderson (D3) 20 |
| 9/2/2010 Pittsburgh 24 at Utah 27 OT |
| 9/3/2010 Wisconsin-Stout (D3) 13 at Black Hills State (NAIA) 14 OT |
| 9/4/2010 Louisiana College (D3) 34 at Belhaven (NAIA) 41 |
| 9/4/2010 Washington 17 at BYU 23 |
| 9/4/2010 Concordia-Moorhead (D3) 24 at Dickinson State (NAIA) 29 |
| 9/4/2010 Cincinnati 14 at Fresno State 28 |
| 9/4/2010 North Dakota State (1AA) 6 at Kansas 3 |
| 9/4/2010 Jacksonville State (1AA) 49 at Mississippi 48 2 OT |
| 9/4/2010 Winston-Salem State (D2) 21 at North Carolina A&T (1AA) 14 |
| 9/4/2010 Menlo (NAIA) 42 at Occidental (D3) 25 |
| 9/4/2010 Azusa Pacific (NAIA) 42 at San Diego (1AA) 14 |
| 9/4/2010 Oregon State 21 vs TCU 30 |
| 9/6/2010 Boise State 33 vs Virginia Tech 30 |
| 9/11/2010 Gardner-Webb (1AA) 38 at Akron 37 OT |
| 9/11/2010 Wagner (1AA) 9 at Assumption (D2) 24 |
| 9/11/2010 La Verne (D3) 14 at Azusa Pacific (NAIA) 59 |
| 9/11/2010 Liberty (1AA) 27 at Ball State 23 |
| 9/11/2010 Miles (D2) 20 at Concordia AL (NAIA) 52 |
| 9/11/2010 Valparaiso (1AA) 7 at Franklin (D3) 42 |
| 9/11/2010 Davidson (1AA) 13 at Lenoir-Rhyne (D2) 41 |
| 9/11/2010 Chapman (D3) 10 at Menlo (NAIA) 21 |
| 9/11/2010 South Dakota (1AA) 41 at Minnesota 38 |
| 9/11/2010 Winston-Salem State (D2) 34 at North Carolina Central (1AA) 27 |
| 9/11/2010 Fort Valley State (D2) 41 vs Savannah State (1AA) 10 |
| 9/11/2010 Southern Oregon (NAIA) 31 at Simon Fraser (D2) 18 |
| 9/11/2010 Arkansas-Monticello (D2) 31 at Southern (1AA) 7 |
| 9/11/2010 James Madison (1AA) 21 at Virginia Tech 16 |
| 9/11/2010 Tusculum (D2) 54 at Western Carolina (1AA) 30 |
| 9/17/2010 California 31 at Nevada 52 |
| 9/17/2010 Kansas 16 at Southern Miss 31 |
| 9/18/2010 Whittier (D3) 21 at Azusa Pacific (NAIA) 46 |
| 9/18/2010 Southern Virginia (NAIA) 20 at Ferrum (D3) 17 |
| 9/18/2010 Anna Maria (D3) 0 at Malone (NAIA) 69 |
| 9/18/2010 Walsh (NAIA) 34 at Notre Dame OH (D2) 14 |
| 9/18/2010 Washington State 21 at SMU 35 |
| 9/18/2010 Nicholls State (1AA) 21 at South Alabama (NAIA) 39 |
| 9/18/2010 Baylor 10 at TCU 45 |
| 9/18/2010 Connecticut 16 at Temple 30 |
| 9/18/2010 Missouri S&T (D2) 10 at Wisconsin-Stevens Point (D3) 29 |
| 9/18/2010 St Joseph's (D2) 50 at Valparaiso (1AA) 7 |
| 9/25/2010 Oregon State 24 at Boise State 37 |
| 9/25/2010 Georgia State (NAIA) 24 at Campbell (1AA) 21 |
| 9/25/2010 Azusa Pacific (NAIA) 35 at Chapman (D3) 17 |
| 9/25/2010 Army 35 at Duke 21 |
| 9/25/2010 Assumption (D2) 30 at Fordham (1AA) 24 |
| 9/25/2010 Bethany KS (NAIA) 38 at MacMurray (D3) 7 |
| 9/25/2010 Northern Illinois 34 at Minnesota 23 |
| 9/25/2010 Langston (NAIA) 30 at Panhandle State (D2) 14 |
| 9/25/2010 North Greenville (D2) 34 at Presbyterian (1AA) 17 |
| 9/25/2010 Toledo 31 at Purdue 20 |
| 9/25/2010 Albany State GA (D2) 28 vs Savannah State (1AA) 14 |
| 9/25/2010 Notre Dame OH (D2) 13 at Taylor (NAIA) 40 |
| 9/25/2010 Texas Southern (1AA) 14 vs Tuskegee (D2) 21 |
| 9/25/2010 Urbana (D2) 33 at Walsh (NAIA) 34 |
| 10/2/2010 Morehead State (1AA) 10 at Georgia State (NAIA) 37 |
| 10/2/2010 Northwestern Oklahoma State (NAIA) 43 at Missouri S&T (D2) 14 |
| 10/2/2010 Tulane 17 at Rutgers 14 |
| 10/2/2010 UC Davis (1AA) 14 at San Jose State 13 |
| 10/2/2010 Kentucky Wesleyan (D2) 3 at South Alabama (NAIA) 52 |
| 10/9/2010 Savannah State (1AA) 21 at Georgia State (NAIA) 55 |
| 10/9/2010 Utah 68 at Iowa State 27 |
| 10/9/2010 Missouri S&T (D2) 6 at South Alabama (NAIA) 45 |
| 10/9/2010 Guilford (D3) 21 at Southern Virginia (NAIA) 36 |
| 10/9/2010 Concordia AL (NAIA) 18 at Stillman (D2) 17 |
| 10/9/2010 Navy 28 at Wake Forest 27 |
| 10/9/2010 UNC Pembroke (D2) 13 at Webber International (NAIA) 26 |
| 10/16/2010 North Carolina State 27 at East Carolina 33 OT |
| 10/16/2010 North Carolina Central (1AA) 17 at Georgia State (NAIA) 20 |
| 10/16/2010 South Alabama (NAIA) 26 at Lamar (1AA) 0 |
| 10/16/2010 Wisconsin-Oshkosh (D3) 35 at Lambuth (D2) 22 |
| 10/23/2010 Notre Dame 17 vs Navy 35 |
| 10/23/2010 Marian IN (NAIA) 35 at Notre Dame OH (D2) 22 |
| 10/23/2010 Lincoln MO (D2) 33 at Peru State (NAIA) 41 |
| 10/23/2010 Missouri S&T (D2) 14 at St Francis IN (NAIA) 41 |
| 10/23/2010 South Alabama (NAIA) 24 at UC Davis (1AA) 21 |
| 10/30/2010 Lincoln MO (D2) 21 at Langston (NAIA) 31 |
| 10/30/2010 Tulsa 28 at Notre Dame 27 |
| 11/6/2010 Lamar (1AA) 17 at Georgia State (NAIA) 23 |
| 11/6/2010 Azusa Pacific (NAIA) 59 at Lincoln MO (D2) 14 |
| 11/6/2010 Panhandle State (D2) 7 at Northwestern Oklahoma State (NAIA) 31 |
| 11/6/2010 Henderson State (D2) 31 at South Alabama (NAIA) 37 |
| 11/11/2010 Arkansas-Monticello (D2) 14 at South Alabama (NAIA) 31 |
| 11/13/2010 Webber International (NAIA) 40 at Apprentice (D3) 7 |
| 11/13/2010 Kentucky Wesleyan (D2) 35 at Concordia AL (NAIA) 36 |
| 11/13/2010 Pacific (D3) 42 at Menlo (NAIA) 44 |
| 11/25/2010 Tuskegee (D2) 17 at Alabama State (1AA) 10 |
| 12/3/2010 Illinois 23 at Fresno State 25 |
| 12/27/2010 Air Force 14 vs Georgia Tech 7 |
| 12/31/2010 UCF 10 vs Georgia 6 |
| 1/1/2011 Wisconsin 19 vs TCU 21 |