| 9/4/2010 | Kentucky Christian Knights 7 @ Walsh 63 | |
| 9/11/2010 | Quincy Hawks 0 @ Walsh 38 | † |
| 9/18/2010 | Walsh 34 @ Notre Dame OH Falcons 14 | |
| 9/25/2010 | Urbana Blue Knights 33 @ Walsh 34 | |
| 10/2/2010 | Walsh 45 @ Olivet Nazarene Tigers 14 | † |
| 10/9/2010 | Walsh 14 @ St Francis IN Fighting Saints 20 | † |
| 10/16/2010 | Taylor Trojans 21 @ Walsh 17 | † |
| 10/23/2010 | Malone Pioneers 21 @ Walsh 24 | † |
| 10/30/2010 | Walsh 10 @ St Xavier Cougars 41 | † |
| 11/6/2010 | Trinity International Trojans 17 @ Walsh 42 | † |
| 11/13/2010 | Walsh 14 @ Marian IN Knights 38 | † |