| 9/4/2010 | Morehead State Eagles 7 @ James Madison 48 | |
| 9/11/2010 | James Madison 21 @ Virginia Tech Hokies 16 | |
| 9/25/2010 | Liberty Flames 3 @ James Madison 10 | |
| 10/2/2010 | Delaware Blue Hens 13 @ James Madison 10 | † |
| 10/9/2010 | James Madison 17 @ Towson Tigers 13 | † |
| 10/16/2010 | New Hampshire Wildcats 28 @ James Madison 14 | † |
| 10/23/2010 | James Madison 7 @ Villanova Wildcats 14 | † |
| 10/30/2010 | Massachusetts Minutemen 21 @ James Madison 14 | † |
| 11/6/2010 | James Madison 10 @ Richmond Spiders 13 1OT | † |
| 11/13/2010 | William & Mary Tribe 24 @ James Madison 30 | † |
| 11/20/2010 | James Madison 14 @ Maine Black Bears 10 | † |