| 9/4/2010 | Oregon State Beavers 21 vs TCU 30 (Arlington TX) | |
| 9/11/2010 | Tennessee Tech Golden Eagles 7 @ TCU 62 | |
| 9/18/2010 | Baylor Bears 10 @ TCU 45 | |
| 9/24/2010 | TCU 41 @ SMU Mustangs 24 | |
| 10/2/2010 | TCU 27 @ Colorado State Rams 0 | † |
| 10/9/2010 | Wyoming Cowboys 0 @ TCU 45 | † |
| 10/16/2010 | BYU Cougars 3 @ TCU 31 | † |
| 10/23/2010 | Air Force Falcons 7 @ TCU 38 | † |
| 10/30/2010 | TCU 40 @ UNLV Rebels 6 | † |
| 11/6/2010 | TCU 47 @ Utah Utes 7 | † |
| 11/13/2010 | San Diego State Aztecs 35 @ TCU 40 | † |
| 11/27/2010 | TCU 66 @ New Mexico Lobos 17 | † |
| 1/1/2011 | Wisconsin Badgers 19 vs TCU 21 (Pasadena - Rose Bowl) |