| 9/4/2010 | Jacksonville State 49 @ Mississippi Rebels 48 2OT | |
| 9/11/2010 | Chattanooga Moccasins 17 @ Jacksonville State 21 | |
| 9/18/2010 | Jacksonville State 34 @ Georgia State Panthers 27 | |
| 9/25/2010 | Jacksonville State 28 @ Eastern Illinois Panthers 23 | † |
| 10/2/2010 | Murray State Racers 34 @ Jacksonville State 40 | † |
| 10/9/2010 | Jacksonville State 30 @ Tennessee-Martin Skyhawks 20 | † |
| 10/16/2010 | Tennessee State Tigers 0 @ Jacksonville State 24 | † |
| 10/23/2010 | Austin Peay Governers 3 @ Jacksonville State 56 | † |
| 11/6/2010 | Jacksonville State 37 @ Eastern Kentucky Colonels 49 | † |
| 11/13/2010 | SE Missouri State Redhawks 27 @ Jacksonville State 29 | † |
| 11/20/2010 | Jacksonville State 24 @ Tennessee Tech Golden Eagles 35 | † |
| 12/4/2010 | Wofford Terriers 17 @ Jacksonville State 14 |