| 9/2/2010 | West Alabama Tigers 27 @ Arkansas-Monticello 20 | † |
| 9/11/2010 | Arkansas-Monticello 31 @ Southern Jaquars 7 | |
| 9/18/2010 | Arkansas-Monticello 37 @ Oauchita Tigers 31 | † |
| 9/25/2010 | Arkansas Tech Wonder Boys 30 @ Arkansas-Monticello 25 | † |
| 10/2/2010 | Arkansas-Monticello 0 @ Henderson State Reddies 47 | † |
| 10/7/2010 | Delta State Statesmen 34 @ Arkansas-Monticello 20 | † |
| 10/16/2010 | West Georgia Wolves 24 @ Arkansas-Monticello 31 | † |
| 10/23/2010 | Arkansas-Monticello 17 @ Valdosta State Blazers 21 | † |
| 10/30/2010 | Arkansas-Monticello 26 @ Harding Bison 33 | † |
| 11/6/2010 | Arkansas-Monticello 28 vs Southern Arkansas Muleriders 23 (El Dorado AR) | † |
| 11/11/2010 | Arkansas-Monticello 14 @ South Alabama Jaguars 31 |