| 9/4/2010 | Cincinnati Bearcats 14 @ Fresno State 28 | |
| 9/18/2010 | Fresno State 41 @ Utah State Aggies 24 | † |
| 9/25/2010 | Fresno State 38 @ Mississippi Rebels 55 | |
| 10/2/2010 | Cal Poly Mustangs 17 @ Fresno State 38 | |
| 10/9/2010 | Hawaii Warriors 49 @ Fresno State 27 | † |
| 10/16/2010 | New Mexico State Aggies 10 @ Fresno State 33 | † |
| 10/23/2010 | Fresno State 33 @ San Jose State Spartans 18 | † |
| 11/6/2010 | Fresno State 40 @ Louisiana Tech Bulldogs 34 | † |
| 11/13/2010 | Nevada Wolf Pack 35 @ Fresno State 34 | † |
| 11/19/2010 | Fresno State 0 @ Boise State Broncos 51 | † |
| 11/27/2010 | Idaho Vandals 20 @ Fresno State 23 | † |
| 12/3/2010 | Illinois Fighting Illini 23 @ Fresno State 25 | |
| 12/18/2010 | Northern Illinois Huskies 40 vs Fresno State 17 (Boise - Humanitarian Bowl) |