| 9/4/2010 | Assumption 33 @ Millersville Marauders 28 | |
| 9/11/2010 | Wagner Seahawks 9 @ Assumption 24 | |
| 9/18/2010 | Assumption 45 @ New Haven Chargers 28 | † |
| 9/25/2010 | Assumption 30 @ Fordham Rams 24 | |
| 10/1/2010 | Assumption 27 @ Southern Connecticut Owls 23 | † |
| 10/9/2010 | Pace Setters 0 @ Assumption 20 | † |
| 10/16/2010 | Assumption 23 @ Merrimack Warriors 49 | † |
| 10/23/2010 | Saint Anselm Hawks 40 @ Assumption 45 | † |
| 10/29/2010 | Bentley Falcons 35 @ Assumption 21 | † |
| 11/6/2010 | Assumption 0 @ Stonehill Skyhawks 18 | † |
| 11/13/2010 | American Int'l Yellow Jackets 35 @ Assumption 10 | † |