| 9/4/2010 | South Dakota Coyotes 7 @ UCF 38 | |
| 9/11/2010 | North Carolina State Wolfpack 28 @ UCF 21 | |
| 9/18/2010 | UCF 24 @ Buffalo Bulls 10 | |
| 9/25/2010 | UCF 13 @ Kansas State Wildcats 17 | |
| 10/6/2010 | UAB Blazers 7 @ UCF 42 | † |
| 10/13/2010 | UCF 35 @ Marshall Thundering Herd 14 | † |
| 10/23/2010 | Rice Owls 14 @ UCF 41 | † |
| 10/30/2010 | East Carolina Pirates 35 @ UCF 49 | † |
| 11/5/2010 | UCF 40 @ Houston Cougars 33 | † |
| 11/13/2010 | Southern Miss Golden Eagles 31 @ UCF 21 | † |
| 11/20/2010 | UCF 61 @ Tulane Green Wave 14 | † |
| 11/27/2010 | UCF 37 @ Memphis Tigers 17 | † |
| 12/4/2010 | SMU Mustangs 7 @ UCF 17 (CUSA Championship) | † |
| 12/31/2010 | UCF 10 vs Georgia Bulldogs 6 (Memphis - Liberty Bowl) |