| 8/28/2010 | Langston 28 @ Incarnate Word Cardinals 20 | |
| 9/4/2010 | Langston 27 @ Alcorn State Braves 50 | |
| 9/25/2010 | Langston 30 @ Panhandle State Aggies 14 | |
| 10/2/2010 | Bacone Warriors 13 @ Langston 14 | † |
| 10/9/2010 | Langston 0 @ Lamar Cardinals 14 | |
| 10/16/2010 | Southwestern Assemblies of God Lions 27 @ Langston 41 | † |
| 10/23/2010 | Northwestern Oklahoma State Rangers 20 @ Langston 13 | † |
| 10/30/2010 | Lincoln MO Blue Tigers 21 @ Langston 31 | |
| 11/6/2010 | Langston 45 @ Texas College Steers 0 | † |
| 11/13/2010 | Langston 27 @ Southern Nazarene Crimson Storm 30 | † |