| 9/2/2010 | Malone 21 @ Tiffin Dragons 31 | |
| 9/11/2010 | Malone 7 @ Saint Ambrose Bees 28 | † |
| 9/18/2010 | Anna Maria Amcats 0 @ Malone 69 | |
| 10/2/2010 | Malone 17 @ St Francis IN Fighting Saints 23 | † |
| 10/9/2010 | Malone 7 @ Taylor Trojans 12 | † |
| 10/16/2010 | St Xavier Cougars 55 @ Malone 16 | † |
| 10/23/2010 | Malone 21 @ Walsh Cavaliers 24 | † |
| 10/30/2010 | Malone 34 @ Trinity International Trojans 0 | † |
| 11/6/2010 | Marian IN Knights 29 @ Malone 7 | † |
| 11/13/2010 | Olivet Nazarene Tigers 21 @ Malone 56 | † |