| 9/3/2010 | Villanova Wildcats 24 @ Temple 31 | |
| 9/9/2010 | Central Michigan Chippewas 10 @ Temple 13 1OT | † |
| 9/18/2010 | Connecticut Huskies 16 @ Temple 30 | |
| 9/25/2010 | Temple 13 @ Penn State Nittany Lions 22 | |
| 10/2/2010 | Temple 42 @ Army Black Knights 35 | |
| 10/9/2010 | Temple 17 @ Northern Illinois Huskies 31 | † |
| 10/16/2010 | Bowling Green Falcons 27 @ Temple 28 | † |
| 10/23/2010 | Temple 42 @ Buffalo Bulls 0 | † |
| 10/30/2010 | Akron Zips 0 @ Temple 30 | † |
| 11/6/2010 | Temple 28 @ Kent State Golden Flashes 10 | † |
| 11/16/2010 | Ohio Bobcats 31 @ Temple 23 | † |
| 11/23/2010 | Temple 3 @ Miami-Ohio Redhawks 23 | † |