| 9/4/2010 | North Dakota State 6 @ Kansas Jayhawks 3 | |
| 9/11/2010 | North Dakota State 9 @ Northern Iowa Panthers 16 | † |
| 9/18/2010 | Morgan State Golden Bears 9 @ North Dakota State 35 | |
| 9/25/2010 | South Dakota Coyotes 16 @ North Dakota State 38 | |
| 10/2/2010 | Western Illinois Leathernecks 28 @ North Dakota State 16 | † |
| 10/9/2010 | North Dakota State 34 @ Youngstown State Penguins 29 | † |
| 10/16/2010 | North Dakota State 24 @ Illinois State Redbirds 34 | † |
| 10/23/2010 | Indiana State Sycamores 15 @ North Dakota State 27 | † |
| 11/6/2010 | Southern Illinois Salukis 6 @ North Dakota State 20 | † |
| 11/13/2010 | South Dakota State Jackrabbits 24 @ North Dakota State 31 | † |
| 11/20/2010 | North Dakota State 0 @ Missouri State Bears 3 | † |
| 11/27/2010 | Robert Morris Colonials 17 @ North Dakota State 43 (FBS Playoffs) | |
| 12/4/2010 | North Dakota State 42 @ Montana State Bobcats 17 | |
| 12/11/2010 | North Dakota State 31 @ Eastern Washington Eagles 38 1OT |