| 9/4/2010 | Pikeville Bears 0 @ South Alabama 56 | |
| 9/18/2010 | Nicholls State Colonels 21 @ South Alabama 39 | |
| 9/25/2010 | Edward Waters Tigers 0 vs South Alabama 64 (Dothan AL) | |
| 10/2/2010 | Kentucky Wesleyan Panthers 3 @ South Alabama 52 | |
| 10/9/2010 | Missouri S&T Miners 6 @ South Alabama 45 | |
| 10/16/2010 | South Alabama 26 @ Lamar Cardinals 0 | |
| 10/23/2010 | South Alabama 24 @ UC Davis Aggies 21 | |
| 10/30/2010 | Georgia State Panthers 34 @ South Alabama 39 | † |
| 11/6/2010 | Henderson State Reddies 31 @ South Alabama 37 | |
| 11/11/2010 | Arkansas-Monticello Boll Weevils 14 @ South Alabama 31 |