| 9/5/2010 | Tulsa Golden Hurricane 49 @ East Carolina 51 | † |
| 9/11/2010 | Memphis Tigers 27 @ East Carolina 49 | † |
| 9/18/2010 | East Carolina 27 @ Virginia Tech Hokies 49 | |
| 10/2/2010 | East Carolina 17 @ North Carolina Tar Heels 42 | |
| 10/9/2010 | East Carolina 44 @ Southern Miss Golden Eagles 43 | † |
| 10/16/2010 | North Carolina State Wolfpack 27 @ East Carolina 33 1OT | |
| 10/23/2010 | Marshall Thundering Herd 10 @ East Carolina 37 | † |
| 10/30/2010 | East Carolina 35 @ UCF Knights 49 | † |
| 11/6/2010 | Navy Midshipmen 76 @ East Carolina 35 | |
| 11/11/2010 | East Carolina 54 @ UAB Blazers 42 | † |
| 11/20/2010 | East Carolina 38 @ Rice Owls 62 | † |
| 11/26/2010 | SMU Mustangs 45 @ East Carolina 38 1OT | † |
| 12/29/2010 | East Carolina 20 vs Maryland Terrapins 51 (Washington DC - Military Bowl) |