| 9/2/2010 | Taylor 42 @ Anderson Ravens 20 | |
| 9/11/2010 | William Penn Statesmen 44 @ Taylor 19 | † |
| 9/18/2010 | Taylor 20 @ Butler Bulldogs 28 | |
| 9/25/2010 | Notre Dame OH Falcons 13 @ Taylor 40 | |
| 10/2/2010 | Taylor 21 @ St Xavier Cougars 46 | † |
| 10/9/2010 | Malone Pioneers 7 @ Taylor 12 | † |
| 10/16/2010 | Taylor 21 @ Walsh Cavaliers 17 | † |
| 10/23/2010 | Taylor 25 @ Trinity International Trojans 10 | † |
| 10/30/2010 | Marian IN Knights 20 @ Taylor 6 | † |
| 11/6/2010 | Olivet Nazarene Tigers 13 @ Taylor 40 | † |
| 11/13/2010 | Taylor 21 @ St Francis IN Fighting Saints 33 | † |