| 8/28/2010 | Virginia Union Panthers 13 vs Winston-Salem State 47 (High Point NC) | † |
| 9/4/2010 | Winston-Salem State 21 @ North Carolina A&T Aggies 14 | |
| 9/11/2010 | Winston-Salem State 34 @ North Carolina Central Eagles 27 | |
| 9/18/2010 | Chowan Braves 7 @ Winston-Salem State 48 | † |
| 9/25/2010 | Winston-Salem State 31 @ Fayetteville State Broncos 14 | † |
| 10/2/2010 | Winston-Salem State 49 @ Johnson C Smith Golden Bulls 3 | † |
| 10/9/2010 | St Augustine's Falcons 40 @ Winston-Salem State 35 | † |
| 10/16/2010 | Livingstone Blue Bears 0 @ Winston-Salem State 58 | † |
| 10/23/2010 | UNC Pembroke Braves 7 @ Winston-Salem State 21 | |
| 10/30/2010 | Winston-Salem State 27 @ Shaw Bears 31 | † |