| 8/28/2010 | Chowan Braves 10 @ Lenoir-Rhyne 59 | |
| 9/4/2010 | Concord Mountain Lions 20 @ Lenoir-Rhyne 17 | |
| 9/11/2010 | Davidson Wildcats 13 @ Lenoir-Rhyne 41 | |
| 9/18/2010 | Lenoir-Rhyne 20 @ North Greenville Crusaders 19 | |
| 10/2/2010 | Lenoir-Rhyne 36 @ Newberry Wolves 40 | † |
| 10/9/2010 | Mars Hill Lions 24 @ Lenoir-Rhyne 20 | † |
| 10/16/2010 | Lenoir-Rhyne 24 @ Brevard Tornados 8 | † |
| 10/23/2010 | Tusculum Pioneers 31 @ Lenoir-Rhyne 34 | † |
| 10/30/2010 | Lenoir-Rhyne 24 @ Wingate Bulldogs 27 | † |
| 11/6/2010 | Lenoir-Rhyne 52 @ Carson-Newman Eagles 14 | † |
| 11/13/2010 | Catawba Indians 17 @ Lenoir-Rhyne 31 | † |