| 9/2/2010 | Eastern Washington Eagles 24 @ Nevada 49 | |
| 9/11/2010 | Colorado State Rams 6 @ Nevada 51 | |
| 9/17/2010 | California Golden Bears 31 @ Nevada 52 | |
| 9/25/2010 | Nevada 27 @ BYU Cougars 13 | |
| 10/2/2010 | Nevada 44 @ UNLV Rebels 26 | |
| 10/9/2010 | San Jose State Spartans 13 @ Nevada 35 | † |
| 10/16/2010 | Nevada 21 @ Hawaii Warriors 27 | † |
| 10/30/2010 | Utah State Aggies 42 @ Nevada 56 | † |
| 11/6/2010 | Nevada 63 @ Idaho Vandals 17 | † |
| 11/13/2010 | Nevada 35 @ Fresno State Bulldogs 34 | † |
| 11/20/2010 | New Mexico State Aggies 6 @ Nevada 52 | † |
| 11/26/2010 | Boise State Broncos 31 @ Nevada 34 1OT | † |
| 12/4/2010 | Nevada 35 @ Louisiana Tech Bulldogs 17 | † |
| 1/9/2011 | Nevada 20 vs Boston College Eagles 13 (San Francisco - Kraft Fight Hunger Bowl) |