| 9/4/2010 | Franklin 27 @ Carthage Red Men 30 | |
| 9/11/2010 | Valparaiso Crusaders 7 @ Franklin 42 | |
| 9/18/2010 | Bluffton Beavers 9 @ Franklin 56 | † |
| 9/25/2010 | Franklin 42 @ Defiance Yellow Jackets 7 | † |
| 10/2/2010 | Franklin 41 @ Mt St Joseph Lions 10 | † |
| 10/9/2010 | Rose-Hulman Engineers 17 @ Franklin 56 | † |
| 10/16/2010 | Franklin 40 @ Manchester Spartans 3 | † |
| 10/30/2010 | Franklin 69 @ Anderson Ravens 10 | † |
| 11/6/2010 | Earlham Hustlin' Quakers 0 @ Franklin 60 | † |
| 11/13/2010 | Hanover Panthers 25 @ Franklin 48 | † |
| 11/20/2010 | Franklin 21 @ Wisconsin-Whitewater Warhawks 52 |