| 9/2/2010 | Northern Illinois 10 @ Iowa State Cyclones 27 | |
| 9/11/2010 | North Dakota Sioux 17 @ Northern Illinois 23 | |
| 9/18/2010 | Northern Illinois 22 @ Illinois Fighting Illini 28 | |
| 9/25/2010 | Northern Illinois 34 @ Minnesota Golden Gophers 23 | |
| 10/2/2010 | Northern Illinois 50 @ Akron Zips 14 | † |
| 10/9/2010 | Temple Owls 17 @ Northern Illinois 31 | † |
| 10/16/2010 | Buffalo Bulls 14 @ Northern Illinois 45 | † |
| 10/23/2010 | Central Michigan Chippewas 7 @ Northern Illinois 33 | † |
| 10/30/2010 | Northern Illinois 28 @ Western Michigan Broncos 21 | † |
| 11/9/2010 | Toledo Rockets 30 @ Northern Illinois 65 | † |
| 11/20/2010 | Northern Illinois 59 @ Ball State Cardinals 21 | † |
| 11/26/2010 | Northern Illinois 71 @ Eastern Michigan Eagles 3 | † |
| 12/3/2010 | Northern Illinois 21 vs Miami-Ohio Redhawks 26 (MAC Championship) | † |
| 12/18/2010 | Northern Illinois 40 vs Fresno State Bulldogs 17 (Boise - Humanitarian Bowl) |