| 8/28/2010 | North Greenville 30 @ Mars Hill Lions 36 | |
| 9/4/2010 | North Greenville 31 @ Charleston Southern Buccaneers 41 | |
| 9/11/2010 | North Greenville 44 @ Edward Waters Tigers 14 | |
| 9/18/2010 | Lenoir-Rhyne Bears 20 @ North Greenville 19 | |
| 9/25/2010 | North Greenville 34 @ Presbyterian Blue Hose 17 | |
| 10/16/2010 | North Greenville 55 @ LaGrange Panthers 27 | |
| 10/23/2010 | Edward Waters Tigers 0 @ North Greenville 42 | |
| 10/30/2010 | North Greenville 21 @ Notre Dame OH Falcons 14 | † |
| 11/6/2010 | North Greenville 27 @ UNC Pembroke Braves 10 | † |
| 11/20/2010 | Campbellsville Tigers 16 @ North Greenville 42 |