| 9/4/2010 | Brevard Tornados 14 @ Gardner-Webb 28 | |
| 9/11/2010 | Gardner-Webb 38 @ Akron Zips 37 1OT | |
| 9/18/2010 | Western Carolina Catamounts 28 @ Gardner-Webb 14 | |
| 9/25/2010 | Gardner-Webb 14 @ Sam Houston Bearkats 30 | |
| 10/2/2010 | Gardner-Webb 7 @ Old Dominion Monarchs 14 | |
| 10/16/2010 | Gardner-Webb 35 @ Charleston Southern Buccaneers 25 | † |
| 10/23/2010 | Presbyterian Blue Hose 26 @ Gardner-Webb 24 | † |
| 10/30/2010 | Coastal Carolina Chanticleers 30 @ Gardner-Webb 27 1OT | † |
| 11/6/2010 | Gardner-Webb 14 @ Liberty Flames 40 | † |
| 11/13/2010 | Gardner-Webb 3 @ Stony Brook Seawolves 55 | † |
| 11/20/2010 | VMI Keydets 7 @ Gardner-Webb 10 | † |