| 9/2/2010 | Southeastern Louisiana Lions 21 @ Tulane 27 | |
| 9/11/2010 | Mississippi Rebels 27 @ Tulane 13 | |
| 9/25/2010 | Tulane 23 @ Houston Cougars 42 | † |
| 10/2/2010 | Tulane 17 @ Rutgers Scarlet Knights 14 | |
| 10/9/2010 | Army Black Knights 41 @ Tulane 23 | |
| 10/16/2010 | Tulane 24 @ Tulsa Golden Hurricane 52 | † |
| 10/23/2010 | Tulane 34 @ UTEP Miners 24 | † |
| 10/30/2010 | SMU Mustangs 31 @ Tulane 17 | † |
| 11/6/2010 | Southern Miss Golden Eagles 46 @ Tulane 30 | † |
| 11/13/2010 | Rice Owls 49 @ Tulane 54 | † |
| 11/20/2010 | UCF Knights 61 @ Tulane 14 | † |
| 11/27/2010 | Tulane 23 @ Marshall Thundering Herd 38 | † |