| 9/5/2010 | Tulsa 49 @ East Carolina Pirates 51 | † |
| 9/11/2010 | Bowling Green Falcons 20 @ Tulsa 33 | |
| 9/18/2010 | Tulsa 28 @ Oklahoma State Cowboys 65 | |
| 9/25/2010 | Central Arkansas Bears 14 @ Tulsa 41 | |
| 10/2/2010 | Tulsa 48 @ Memphis Tigers 7 | † |
| 10/9/2010 | Tulsa 18 @ SMU Mustangs 21 | † |
| 10/16/2010 | Tulane Green Wave 24 @ Tulsa 52 | † |
| 10/30/2010 | Tulsa 28 @ Notre Dame Fighting Irish 27 | |
| 11/6/2010 | Rice Owls 27 @ Tulsa 64 | † |
| 11/13/2010 | Tulsa 28 @ Houston Cougars 25 | † |
| 11/20/2010 | UTEP Miners 28 @ Tulsa 31 | † |
| 11/26/2010 | Southern Miss Golden Eagles 50 @ Tulsa 56 | † |
| 12/24/2010 | Hawaii Warriors 35 vs Tulsa 62 (Honolulu - Hawaii Bowl) |