| 9/4/2010 | South Dakota 7 @ UCF Knights 38 | |
| 9/11/2010 | South Dakota 41 @ Minnesota Golden Gophers 38 | |
| 9/18/2010 | Northwestern Oklahoma State Rangers 14 @ South Dakota 48 | |
| 9/25/2010 | South Dakota 16 @ North Dakota State Bison 38 | |
| 10/2/2010 | North Dakota Sioux 17 @ South Dakota 27 | † |
| 10/9/2010 | South Dakota 13 @ UC Davis Aggies 17 | † |
| 10/16/2010 | Northern Iowa Panthers 19 @ South Dakota 14 | |
| 10/23/2010 | South Dakota 13 @ Southern Utah Thunderbirds 31 | † |
| 10/30/2010 | Northern Colorado Bears 6 @ South Dakota 34 | |
| 11/6/2010 | Cal Poly Mustangs 38 @ South Dakota 24 | † |
| 11/13/2010 | South Dakota 20 @ Lamar Cardinals 24 |