| 9/5/2010 | SMU 27 @ Texas Tech Red Raiders 35 | |
| 9/11/2010 | UAB Blazers 7 @ SMU 28 | † |
| 9/18/2010 | Washington State Cougars 21 @ SMU 35 | |
| 9/24/2010 | TCU Horned Frogs 41 @ SMU 24 | |
| 10/2/2010 | SMU 42 @ Rice Owls 31 | † |
| 10/9/2010 | Tulsa Golden Hurricane 18 @ SMU 21 | † |
| 10/16/2010 | SMU 21 @ Navy Midshipmen 28 | |
| 10/23/2010 | Houston Cougars 45 @ SMU 20 | † |
| 10/30/2010 | SMU 31 @ Tulane Green Wave 17 | † |
| 11/6/2010 | SMU 14 @ UTEP Miners 28 | † |
| 11/20/2010 | Marshall Thundering Herd 17 @ SMU 31 | † |
| 11/26/2010 | SMU 45 @ East Carolina Pirates 38 1OT | † |
| 12/4/2010 | SMU 7 @ UCF Knights 17 (CUSA Championship) | † |
| 12/30/2010 | Army Black Knights 16 vs SMU 14 (Fort Worth - Armed Forces Bowl) |