| 8/28/2010 | Southern Oregon 34 @ Eastern Oregon Mountaineers 30 | |
| 9/11/2010 | Southern Oregon 31 @ Simon Fraser Clan 18 | |
| 9/18/2010 | Southern Oregon 24 @ Willamette Bearcats 42 | |
| 9/25/2010 | Menlo Oaks 20 @ Southern Oregon 13 | † |
| 10/2/2010 | Western Oregon Runnin' Wolves 24 @ Southern Oregon 23 | |
| 10/9/2010 | Southern Oregon 0 @ Central Washington Wildcats 27 | |
| 10/16/2010 | Mary Hardin-Baylor Crusaders 31 @ Southern Oregon 10 | |
| 10/30/2010 | Azusa Pacific Cougars 38 @ Southern Oregon 13 | † |
| 11/6/2010 | Southern Oregon 24 @ Menlo Oaks 13 | † |
| 11/13/2010 | Southern Oregon 26 @ Northwestern Oklahoma State Rangers 31 |