| 8/28/2010 | Truman State Bulldogs 23 @ St Joseph's 13 | |
| 9/4/2010 | St Joseph's 7 @ Indiana State Sycamores 57 | |
| 9/11/2010 | St Joseph's 0 @ Shepherd Rams 55 | |
| 9/18/2010 | St Joseph's 50 @ Valparaiso Crusaders 7 | |
| 10/2/2010 | St Joseph's 58 @ Lincoln MO Blue Tigers 22 | |
| 10/9/2010 | Notre Dame OH Falcons 7 @ St Joseph's 37 | |
| 10/16/2010 | Urbana Blue Knights 20 @ St Joseph's 27 | † |
| 10/23/2010 | St Joseph's 43 @ Kentucky Wesleyan Panthers 35 | † |
| 10/30/2010 | St Joseph's 43 @ Southwest Baptist Bearcats 51 | |
| 11/6/2010 | Missouri S&T Miners 27 @ St Joseph's 21 | † |