| 8/28/2010 | Concordia NE Bulldogs 13 @ Peru State 7 | |
| 9/4/2010 | Peru State 54 @ Jamestown Jimmies 56 | |
| 9/11/2010 | Buena Vista Beavers 27 vs Peru State 7 (Falls City NE) | |
| 9/18/2010 | Peru State 10 @ Sterling Warriors 17 | |
| 10/2/2010 | Tabor Bluejays 45 @ Peru State 48 | |
| 10/9/2010 | Peru State 24 @ Culver-Stockton Wildcats 14 | |
| 10/16/2010 | Peru State 13 @ Friends Falcons 38 | |
| 10/23/2010 | Lincoln MO Blue Tigers 33 @ Peru State 41 | |
| 10/30/2010 | Peru State 6 @ William Penn Statesmen 70 | |
| 11/6/2010 | Benedictine KS Ravens 28 @ Peru State 0 | |
| 11/13/2010 | Haskell Indians 3 @ Peru State 20 | † |