| 9/2/2010 | Northern Illinois Huskies 10 @ Iowa State 27 | |
| 9/4/2010 | Sam Houston Bearkats 3 @ Baylor 34 | |
| 9/4/2010 | Colorado State Rams 3 vs Colorado 24 (Denver CO) | |
| 9/4/2010 | North Dakota State Bison 6 @ Kansas 3 | |
| 9/4/2010 | UCLA Bruins 22 @ Kansas State 31 | |
| 9/4/2010 | Illinois Fighting Illini 13 vs Missouri 23 (St Louis MO) | |
| 9/4/2010 | Western Kentucky Hilltoppers 10 @ Nebraska 49 | |
| 9/4/2010 | Utah State Aggies 24 @ Oklahoma 31 | |
| 9/4/2010 | Washington State Cougars 17 @ Oklahoma State 65 | |
| 9/4/2010 | Texas 34 @ Rice Owls 17 | |
| 9/4/2010 | Stephen F. Austin Lumberjacks 7 @ Texas A&M 48 | |
| 9/5/2010 | SMU Mustangs 27 @ Texas Tech 35 | |
| 9/11/2010 | Buffalo Bulls 6 @ Baylor 34 | |
| 9/11/2010 | Colorado 7 @ California Golden Bears 52 | |
| 9/11/2010 | Iowa State 7 @ Iowa Hawkeyes 35 | |
| 9/11/2010 | Georgia Tech Yellow Jackets 25 @ Kansas 28 | |
| 9/11/2010 | Missouri State Bears 24 @ Kansas State 48 | |
| 9/11/2010 | McNeese State Cowboys 6 @ Missouri 50 | |
| 9/11/2010 | Idaho Vandals 17 @ Nebraska 38 | |
| 9/11/2010 | Texas Tech 52 @ New Mexico Lobos 17 | |
| 9/11/2010 | Florida State Seminoles 17 @ Oklahoma 47 | |
| 9/11/2010 | Troy Trojans 38 @ Oklahoma State 41 | |
| 9/11/2010 | Wyoming Cowboys 7 @ Texas 34 | |
| 9/11/2010 | Louisiana Tech Bulldogs 16 @ Texas A&M 48 | |
| 9/17/2010 | Kansas 16 @ Southern Miss Golden Eagles 31 | |
| 9/18/2010 | Hawaii Warriors 13 @ Colorado 31 | |
| 9/18/2010 | Iowa State 20 vs Kansas State 27 (Kansas City MO) | † |
| 9/18/2010 | San Diego State Aztecs 24 @ Missouri 27 | |
| 9/18/2010 | Air Force Falcons 24 @ Oklahoma 27 | |
| 9/18/2010 | Tulsa Golden Hurricane 28 @ Oklahoma State 65 | |
| 9/18/2010 | Baylor 10 @ TCU Horned Frogs 45 | |
| 9/18/2010 | Florida Intl Golden Panthers 20 @ Texas A&M 27 | |
| 9/18/2010 | Texas 24 @ Texas Tech 14 | † |
| 9/18/2010 | Nebraska 56 @ Washington Huskies 21 | |
| 9/25/2010 | Oklahoma 31 @ Cincinnati Bearcats 29 | |
| 9/25/2010 | Northern Iowa Panthers 0 @ Iowa State 27 | |
| 9/25/2010 | New Mexico State Aggies 16 @ Kansas 42 | |
| 9/25/2010 | UCF Knights 13 @ Kansas State 17 | |
| 9/25/2010 | Miami-Ohio Redhawks 13 @ Missouri 51 | |
| 9/25/2010 | South Dakota State Jackrabbits 3 @ Nebraska 17 | |
| 9/25/2010 | Baylor 30 @ Rice Owls 13 | |
| 9/25/2010 | UCLA Bruins 34 @ Texas 12 | |
| 9/30/2010 | Texas A&M 35 @ Oklahoma State 38 | † |
| 10/2/2010 | Kansas 7 @ Baylor 55 | † |
| 10/2/2010 | Georgia Bulldogs 27 @ Colorado 29 | |
| 10/2/2010 | Texas Tech 38 @ Iowa State 52 | † |
| 10/2/2010 | Oklahoma 28 vs Texas 20 (Dallas TX) | † |
| 10/7/2010 | Nebraska 48 @ Kansas State 13 | † |
| 10/8/2010 | Oklahoma State 54 @ UL Lafayette Ragin' Cajuns 28 | |
| 10/9/2010 | Texas Tech 45 vs Baylor 38 (Dallas TX) | † |
| 10/9/2010 | Utah Utes 68 @ Iowa State 27 | |
| 10/9/2010 | Colorado 0 @ Missouri 26 | † |
| 10/9/2010 | Arkansas Razorbacks 24 vs Texas A&M 17 (Arlington TX) | |
| 10/14/2010 | Kansas State 59 @ Kansas 7 | † |
| 10/16/2010 | Baylor 31 @ Colorado 25 | † |
| 10/16/2010 | Texas 20 @ Nebraska 13 | † |
| 10/16/2010 | Iowa State 0 @ Oklahoma 52 | † |
| 10/16/2010 | Missouri 30 @ Texas A&M 9 | † |
| 10/16/2010 | Oklahoma State 34 @ Texas Tech 17 | † |
| 10/23/2010 | Kansas State 42 @ Baylor 47 | † |
| 10/23/2010 | Texas Tech 27 @ Colorado 24 | † |
| 10/23/2010 | Texas A&M 45 @ Kansas 10 | † |
| 10/23/2010 | Oklahoma 27 @ Missouri 36 | † |
| 10/23/2010 | Nebraska 51 @ Oklahoma State 41 | † |
| 10/23/2010 | Iowa State 28 @ Texas 21 | † |
| 10/30/2010 | Kansas 16 @ Iowa State 28 | † |
| 10/30/2010 | Oklahoma State 24 @ Kansas State 14 | † |
| 10/30/2010 | Missouri 17 @ Nebraska 31 | † |
| 10/30/2010 | Colorado 10 @ Oklahoma 43 | † |
| 10/30/2010 | Baylor 30 @ Texas 22 | † |
| 10/30/2010 | Texas Tech 27 @ Texas A&M 45 | † |
| 11/6/2010 | Nebraska 31 @ Iowa State 30 1OT | † |
| 11/6/2010 | Colorado 45 @ Kansas 52 | † |
| 11/6/2010 | Texas 14 @ Kansas State 39 | † |
| 11/6/2010 | Baylor 28 @ Oklahoma State 55 | † |
| 11/6/2010 | Oklahoma 19 @ Texas A&M 33 | † |
| 11/6/2010 | Missouri 17 @ Texas Tech 24 | † |
| 11/13/2010 | Texas A&M 42 @ Baylor 30 | † |
| 11/13/2010 | Iowa State 14 @ Colorado 34 | † |
| 11/13/2010 | Kansas State 28 @ Missouri 38 | † |
| 11/13/2010 | Kansas 3 @ Nebraska 20 | † |
| 11/13/2010 | Texas Tech 7 @ Oklahoma 45 | † |
| 11/13/2010 | Oklahoma State 33 @ Texas 16 | † |
| 11/20/2010 | Oklahoma 53 @ Baylor 24 | † |
| 11/20/2010 | Kansas State 36 @ Colorado 44 | † |
| 11/20/2010 | Missouri 14 @ Iowa State 0 | † |
| 11/20/2010 | Oklahoma State 48 @ Kansas 14 | † |
| 11/20/2010 | Florida Atlantic Owls 17 @ Texas 51 | |
| 11/20/2010 | Nebraska 6 @ Texas A&M 9 | † |
| 11/20/2010 | Weber State Wildcats 21 @ Texas Tech 58 | |
| 11/25/2010 | Texas A&M 24 @ Texas 17 | † |
| 11/26/2010 | Colorado 17 @ Nebraska 45 | † |
| 11/27/2010 | Missouri 35 vs Kansas 7 (Kansas City MO) | † |
| 11/27/2010 | Kansas State 49 @ North Texas Eagles 41 | |
| 11/27/2010 | Oklahoma 47 @ Oklahoma State 41 | † |
| 11/27/2010 | Houston Cougars 20 @ Texas Tech 35 | |
| 12/4/2010 | Nebraska 20 vs Oklahoma 23 (Arlington TX-Big 12 Championship ) | † |
| 12/28/2010 | Missouri 24 vs Iowa Hawkeyes 27 (Phoenix - Insight Bowl) | |
| 12/29/2010 | Oklahoma State 36 vs Arizona Wildcats 10 (San Antonio - Alamo Bowl) | |
| 12/29/2010 | Illinois Fighting Illini 38 vs Baylor 14 (Houston - Texas Bowl) | |
| 12/30/2010 | Kansas State 34 vs Syracuse Orangemen 36 (New York - Pinstripe Bowl) | |
| 12/30/2010 | Nebraska 7 vs Washington Huskies 19 (San Diego - Holiday Bowl) | |
| 1/1/2011 | Connecticut Huskies 20 vs Oklahoma 48 (Glendale - Fiesta Bowl) | |
| 1/1/2011 | Northwestern Wildcats 38 vs Texas Tech 45 (Dallas - TicketCity Bowl) | |
| 1/7/2011 | LSU Tigers 41 vs Texas A&M 24 (Dallas - Cotton Bowl) |