| 9/11/2010 | Rutgers Scarlet Knights 19 @ Florida Intl 14 | |
| 9/18/2010 | Florida Intl 20 @ Texas A&M Aggies 27 | |
| 9/25/2010 | Florida Intl 28 @ Maryland Terrapins 42 | |
| 10/2/2010 | Florida Intl 17 @ Pittsburgh Panthers 44 | |
| 10/9/2010 | Western Kentucky Hilltoppers 21 @ Florida Intl 28 | † |
| 10/16/2010 | Florida Intl 34 @ North Texas Eagles 10 | † |
| 10/30/2010 | Florida Intl 9 @ Florida Atlantic Owls 21 | † |
| 11/6/2010 | UL Monroe Warhawks 35 @ Florida Intl 42 2OT | † |
| 11/13/2010 | Florida Intl 52 @ Troy Trojans 35 | † |
| 11/20/2010 | Florida Intl 38 @ UL Lafayette Ragin' Cajuns 17 | † |
| 11/27/2010 | Arkansas State Red Wolves 24 @ Florida Intl 31 | † |
| 12/4/2010 | Middle Tenn State Blue Raiders 28 @ Florida Intl 27 | † |
| 12/26/2010 | Florida Intl 34 vs Toledo Rockets 32 (Detroit - Little Ceasar's Bowl) |