| 9/4/2010 | UL Lafayette 7 @ Georgia Bulldogs 55 | |
| 9/11/2010 | Arkansas State Red Wolves 24 @ UL Lafayette 31 | † |
| 9/25/2010 | Middle Tenn State Blue Raiders 34 @ UL Lafayette 14 | † |
| 10/2/2010 | UL Lafayette 28 @ North Texas Eagles 27 | † |
| 10/8/2010 | Oklahoma State Cowboys 54 @ UL Lafayette 28 | |
| 10/16/2010 | UL Lafayette 24 @ Troy Trojans 31 | † |
| 10/23/2010 | Western Kentucky Hilltoppers 54 @ UL Lafayette 21 | † |
| 10/30/2010 | UL Lafayette 31 @ Ohio Bobcats 38 | |
| 11/6/2010 | UL Lafayette 21 @ Mississippi Rebels 43 | |
| 11/13/2010 | UL Lafayette 23 @ Florida Atlantic Owls 24 | † |
| 11/20/2010 | Florida Intl Golden Panthers 38 @ UL Lafayette 17 | † |
| 11/27/2010 | UL Lafayette 23 @ UL Monroe Warhawks 22 | † |