| 9/4/2010 | Syracuse 29 @ Akron Zips 3 | |
| 9/11/2010 | Syracuse 20 @ Washington Huskies 41 | |
| 9/18/2010 | Maine Black Bears 14 @ Syracuse 38 | |
| 9/25/2010 | Colgate Red Raiders 7 @ Syracuse 42 | |
| 10/9/2010 | Syracuse 13 @ South Florida Bulls 9 | † |
| 10/16/2010 | Pittsburgh Panthers 45 @ Syracuse 14 | † |
| 10/23/2010 | Syracuse 19 @ West Virginia Mountaineers 14 | † |
| 10/30/2010 | Syracuse 31 @ Cincinnati Bearcats 7 | † |
| 11/6/2010 | Louisville Cardinals 28 @ Syracuse 20 | † |
| 11/13/2010 | Syracuse 13 @ Rutgers Scarlet Knights 10 | † |
| 11/20/2010 | Connecticut Huskies 23 @ Syracuse 6 | † |
| 11/27/2010 | Boston College Eagles 16 @ Syracuse 7 | |
| 12/30/2010 | Kansas State Wildcats 34 vs Syracuse 36 (New York - Pinstripe Bowl) |