| 9/4/2010 | Texas State Bobcats 28 @ Houston 68 | |
| 9/10/2010 | UTEP Miners 24 @ Houston 54 | † |
| 9/18/2010 | Houston 13 @ UCLA Bruins 31 | |
| 9/25/2010 | Tulane Green Wave 23 @ Houston 42 | † |
| 10/9/2010 | Mississippi State Bulldogs 47 @ Houston 24 | |
| 10/16/2010 | Houston 31 @ Rice Owls 34 | † |
| 10/23/2010 | Houston 45 @ SMU Mustangs 20 | † |
| 10/30/2010 | Houston 56 @ Memphis Tigers 17 | † |
| 11/5/2010 | UCF Knights 40 @ Houston 33 | † |
| 11/13/2010 | Tulsa Golden Hurricane 28 @ Houston 25 | † |
| 11/20/2010 | Houston 41 @ Southern Miss Golden Eagles 59 | † |
| 11/27/2010 | Houston 20 @ Texas Tech Red Raiders 35 |