| 9/4/2010 | Bowling Green Falcons 27 @ Troy 30 | |
| 9/11/2010 | Troy 38 @ Oklahoma State Cowboys 41 | |
| 9/18/2010 | Troy 33 @ UAB Blazers 34 | |
| 9/25/2010 | Arkansas State Red Wolves 28 @ Troy 35 | † |
| 10/5/2010 | Troy 42 @ Middle Tenn State Blue Raiders 13 | † |
| 10/16/2010 | UL Lafayette Ragin' Cajuns 24 @ Troy 31 | † |
| 10/30/2010 | Troy 14 @ UL Monroe Warhawks 28 | † |
| 11/6/2010 | Troy 41 @ North Texas Eagles 35 | † |
| 11/13/2010 | Florida Intl Golden Panthers 52 @ Troy 35 | † |
| 11/20/2010 | Troy 24 @ South Carolina Gamecocks 69 | |
| 11/27/2010 | Western Kentucky Hilltoppers 14 @ Troy 28 | † |
| 12/4/2010 | Troy 44 @ Florida Atlantic Owls 7 | † |
| 12/18/2010 | Ohio Bobcats 21 vs Troy 48 (New Orleans - New Orleans Bowl) |