| 9/4/2010 | Northwestern 23 @ Vanderbilt Commodores 21 | |
| 9/11/2010 | Illinois State Redbirds 3 @ Northwestern 37 | |
| 9/18/2010 | Northwestern 30 @ Rice Owls 13 | |
| 9/25/2010 | Central Michigan Chippewas 25 @ Northwestern 30 | |
| 10/2/2010 | Northwestern 29 @ Minnesota Golden Gophers 28 | † |
| 10/9/2010 | Purdue Boilermakers 20 @ Northwestern 17 | † |
| 10/23/2010 | Michigan State Spartans 35 @ Northwestern 27 | † |
| 10/30/2010 | Northwestern 20 @ Indiana Hoosiers 17 | † |
| 11/6/2010 | Northwestern 21 @ Penn State Nittany Lions 35 | † |
| 11/13/2010 | Iowa Hawkeyes 17 @ Northwestern 21 | † |
| 11/20/2010 | Illinois Fighting Illini 48 @ Northwestern 27 | † |
| 11/27/2010 | Northwestern 23 @ Wisconsin Badgers 70 | † |
| 1/1/2011 | Northwestern 38 vs Texas Tech Red Raiders 45 (Dallas - TicketCity Bowl) |