| 9/4/2010 | Southern Utah Thunderbirds 20 @ Wyoming 28 | |
| 9/11/2010 | Wyoming 7 @ Texas Longhorns 34 | |
| 9/18/2010 | Boise State Broncos 51 @ Wyoming 6 | |
| 9/25/2010 | Air Force Falcons 20 @ Wyoming 14 | † |
| 10/2/2010 | Wyoming 20 @ Toledo Rockets 15 | |
| 10/9/2010 | Wyoming 0 @ TCU Horned Frogs 45 | † |
| 10/16/2010 | Utah Utes 30 @ Wyoming 6 | † |
| 10/23/2010 | Wyoming 20 @ BYU Cougars 25 | † |
| 10/30/2010 | San Diego State Aztecs 48 @ Wyoming 38 | † |
| 11/6/2010 | Wyoming 31 @ New Mexico Lobos 34 | † |
| 11/13/2010 | Wyoming 16 @ UNLV Rebels 42 | † |
| 11/20/2010 | Colorado State Rams 0 @ Wyoming 44 | † |