| 9/4/2010 | Cincinnati 14 @ Fresno State Bulldogs 28 | |
| 9/11/2010 | Indiana State Sycamores 7 @ Cincinnati 40 | |
| 9/16/2010 | Cincinnati 19 @ North Carolina State Wolfpack 30 | |
| 9/25/2010 | Oklahoma Sooners 31 @ Cincinnati 29 | |
| 10/9/2010 | Miami-Ohio Redhawks 3 @ Cincinnati 45 | |
| 10/15/2010 | Cincinnati 35 @ Louisville Cardinals 27 | † |
| 10/22/2010 | South Florida Bulls 38 @ Cincinnati 30 | † |
| 10/30/2010 | Syracuse Orangemen 31 @ Cincinnati 7 | † |
| 11/13/2010 | Cincinnati 10 @ West Virginia Mountaineers 37 | † |
| 11/20/2010 | Rutgers Scarlet Knights 38 @ Cincinnati 69 | † |
| 11/27/2010 | Cincinnati 17 @ Connecticut Huskies 38 | † |
| 12/4/2010 | Pittsburgh Panthers 28 @ Cincinnati 10 | † |