| 9/4/2010 | Nicholls State Colonels 0 @ San Diego State 47 | |
| 9/11/2010 | San Diego State 41 @ New Mexico State Aggies 21 | |
| 9/18/2010 | San Diego State 24 @ Missouri Tigers 27 | |
| 9/25/2010 | Utah State Aggies 7 @ San Diego State 41 | |
| 10/9/2010 | San Diego State 21 @ BYU Cougars 24 | † |
| 10/16/2010 | Air Force Falcons 25 @ San Diego State 27 | † |
| 10/23/2010 | San Diego State 30 @ New Mexico Lobos 20 | † |
| 10/30/2010 | San Diego State 48 @ Wyoming Cowboys 38 | † |
| 11/6/2010 | Colorado State Rams 19 @ San Diego State 24 | † |
| 11/13/2010 | San Diego State 35 @ TCU Horned Frogs 40 | † |
| 11/20/2010 | Utah Utes 38 @ San Diego State 34 | † |
| 11/27/2010 | UNLV Rebels 14 @ San Diego State 48 | † |
| 12/23/2010 | Navy Midshipmen 14 vs San Diego State 35 (San Diego - Poinsettia Bowl) |