| 9/4/2010 | Samford Bulldogs 6 @ Florida State 59 | |
| 9/11/2010 | Florida State 17 @ Oklahoma Sooners 47 | |
| 9/18/2010 | BYU Cougars 10 @ Florida State 34 | |
| 9/25/2010 | Wake Forest Demon Deacons 0 @ Florida State 31 | † |
| 10/2/2010 | Florida State 34 @ Virginia Cavaliers 14 | † |
| 10/9/2010 | Florida State 45 @ Miami-Florida Hurricanes 17 | † |
| 10/16/2010 | Boston College Eagles 19 @ Florida State 24 | † |
| 10/28/2010 | Florida State 24 @ North Carolina State Wolfpack 28 | † |
| 11/6/2010 | North Carolina Tar Heels 37 @ Florida State 35 | † |
| 11/13/2010 | Clemson Tigers 13 @ Florida State 16 | † |
| 11/20/2010 | Florida State 30 @ Maryland Terrapins 16 | † |
| 11/27/2010 | Florida Gators 7 @ Florida State 31 | |
| 12/4/2010 | Florida State 33 vs Virginia Tech Hokies 44 (Charlotte NC-ACC Championship) | † |
| 12/31/2010 | South Carolina Gamecocks 17 vs Florida State 26 (Atlanta - Chik Fil-A Bowl) |