| 9/4/2010 | Lamar Cardinals 27 @ McNeese State 30 | † |
| 9/11/2010 | McNeese State 6 @ Missouri Tigers 50 | |
| 9/25/2010 | Cal Poly Mustangs 40 @ McNeese State 14 | |
| 10/2/2010 | McNeese State 24 @ Northwestern State Demons 7 | † |
| 10/9/2010 | Stephen F. Austin Lumberjacks 32 @ McNeese State 27 | † |
| 10/16/2010 | McNeese State 10 @ LSU Tigers 32 | |
| 10/23/2010 | McNeese State 13 @ Southeastern Louisiana Lions 10 | † |
| 10/30/2010 | Nicholls State Colonels 14 @ McNeese State 24 | † |
| 11/6/2010 | McNeese State 33 @ Sam Houston Bearkats 28 | † |
| 11/13/2010 | Texas State Bobcats 6 @ McNeese State 36 | † |
| 11/20/2010 | McNeese State 24 @ Central Arkansas Bears 28 | † |