| 9/3/2010 | Eastern Kentucky Colonels 9 @ Missouri State 31 | |
| 9/11/2010 | Missouri State 24 @ Kansas State Wildcats 48 | |
| 9/25/2010 | Missouri State 41 @ Illinois State Redbirds 44 1OT | † |
| 10/2/2010 | Youngstown State Penguins 25 @ Missouri State 35 | † |
| 10/9/2010 | Missouri State 59 @ Murray State Racers 72 | |
| 10/16/2010 | Missouri State 35 @ Indiana State Sycamores 38 | † |
| 10/23/2010 | Western Illinois Leathernecks 28 @ Missouri State 31 | † |
| 10/30/2010 | Southern Illinois Salukis 41 @ Missouri State 51 | † |
| 11/6/2010 | Missouri State 10 @ South Dakota State Jackrabbits 31 | † |
| 11/13/2010 | Missouri State 14 @ Northern Iowa Panthers 38 | † |
| 11/20/2010 | North Dakota State Bison 0 @ Missouri State 3 | † |