| 9/4/2010 | Louisiana Tech 20 vs Grambling Tigers 6 (Shreveport LA) | |
| 9/11/2010 | Louisiana Tech 16 @ Texas A&M Aggies 48 | |
| 9/18/2010 | Navy Midshipmen 37 @ Louisiana Tech 23 | |
| 9/25/2010 | Southern Miss Golden Eagles 13 @ Louisiana Tech 12 | |
| 10/2/2010 | Louisiana Tech 21 @ Hawaii Warriors 41 | † |
| 10/9/2010 | Utah State Aggies 6 @ Louisiana Tech 24 | † |
| 10/16/2010 | Idaho Vandals 35 @ Louisiana Tech 48 | † |
| 10/26/2010 | Louisiana Tech 20 @ Boise State Broncos 49 | † |
| 11/6/2010 | Fresno State Bulldogs 40 @ Louisiana Tech 34 | † |
| 11/13/2010 | Louisiana Tech 41 @ New Mexico State Aggies 20 | † |
| 11/27/2010 | Louisiana Tech 45 @ San Jose State Spartans 38 | † |
| 12/4/2010 | Nevada Wolf Pack 35 @ Louisiana Tech 17 | † |