| 9/2/2010 | Southern California Trojans 49 @ Hawaii 36 | |
| 9/11/2010 | Hawaii 31 @ Army Black Knights 28 | |
| 9/18/2010 | Hawaii 13 @ Colorado Buffaloes 31 | |
| 9/25/2010 | Charleston Southern Buccaneers 7 @ Hawaii 66 | |
| 10/2/2010 | Louisiana Tech Bulldogs 21 @ Hawaii 41 | † |
| 10/9/2010 | Hawaii 49 @ Fresno State Bulldogs 27 | † |
| 10/16/2010 | Nevada Wolf Pack 21 @ Hawaii 27 | † |
| 10/23/2010 | Hawaii 45 @ Utah State Aggies 7 | † |
| 10/30/2010 | Idaho Vandals 10 @ Hawaii 45 | † |
| 11/6/2010 | Hawaii 7 @ Boise State Broncos 42 | † |
| 11/20/2010 | San Jose State Spartans 7 @ Hawaii 41 | † |
| 11/27/2010 | Hawaii 59 @ New Mexico State Aggies 24 | † |
| 12/4/2010 | UNLV Rebels 21 @ Hawaii 59 | |
| 12/24/2010 | Hawaii 35 vs Tulsa Golden Hurricane 62 (Honolulu - Hawaii Bowl) |